Like Janeane Garofalo, while her politics can be vile/obnoxious, I could see Silverman doing fairly well in this.
Black's got great comic timing, though, Bane. Not sure why you're underwhelmed by that suggestion.
Sandra Bullock, herself, has, too.
It's weird how a lot of people just want female actress X, Y and Z to be in this, purely because of attractiveness, when a big part of what made the original ensemble of slacker types work, was how average-looking they all were. No matter who gets cast in this, it needs a sibling vibe between the lead characters. That was the biggest key behind why the differing personalities worked.
