Infestation pulls comparisons from Metroid, Contra, and Castlevania...all of those are benchmark series from the 8-bit and 16-bit era. It seems like the only significant shortcoming of this game (based on this review) has more to do with the limitations of the DS hardware (audio capabilities) than it does with the actual gameplay mechanics. I'm not surprised that the story has been criticized for lacking substance...with the exception of only some games from the Metroid series, both Contra and Castlevania were never regarded as stellar examples of good story lines being told through video games. As a matter of fact, I think most story lines for 2D platformers are garbage. If you want a good story, you are better off trying your luck with RPGs.
Overall, it sounds like this game will be all that I hoped/expected it would be. I'm looking forward to owning it.