Taking a quick detour and making a less serious movie can work, if done right, and with respect for the franchise. Jeunet handled the "wacky" aspects of Resurrection fairly well. But mixed in with all that humorous business, was some very serious content and a basically watchable alien story. Anderson had it in him (at the time) to make a good movie out of AVP, but for reasons that others could no doubt explain much better than I, it just didn't work out that way. His work with the RE movies definitely confirms (for me) that he is certainly no longer a good choice for any future films.
But, Anderson didn't flat-out murder the entire thing like Black did with The Predator. I'll give him that. And at least Jeunet kept the humor under control. Granted, it still felt more like one of the novels than the other films. It was cheesy, but workable cheesy.