I've never had a problem with the "modern day Earth" setting for AVP stories, be they movies, comics, games or whatever, especially since that's been the setting for almost every Predator movie so far. I never much cared for the whole "ancient temple" angle of the first film though. At least AVP:R was set in a recognisable
modern day Earth, though frankly even if you hated that particular aspect of the film you have to admit it was the least of its problems.
But obviously an AVP movie set in the future would be cool, since as you say that's where the majority of comic and games have taken place.
At this point though I just wonder if they ever would or could justify the sort of budget they'd need to properly realise that concept on-screen.