The suburbs is a little worrying maybe because as a setting it seems too familiar and ordinary for an exotic character like the Predator. Like putting Chewbacca in a gas station. Sure, Predator 2 was set in an urban landscape, but it was also set in the future and there was a lot about the LA of that film that seemed alien, weird, tribal, extreme, etc.
Maybe its possible to make the suburbs seem weird and tribal too. Maybe it would look that way to the Predators.
Or maybe it'll be Monster Squad 2.