What I'd love to see (and I've been saying it for years) is reversed scenario. Make Predator on the run. Show us super prepared human task force with equipment and man power to actually go after predator. Go big! Give them tanks and choopers! Make the creature vulnerable, wounded and chased. Then reverse the plot again and show us the Predator live up to its name! Garber was told he'll get another chance and I want this chance taken.
Indeed. As I like to call it the "X-Com" scenario. Humans learning to turn the tables on a larger scale... Though I don't know about tanks.
Predator set's the story in place, Predator 2, on some level, gave us two hints at threads. The fact Predators have been on Earth a long time, and that there is government activity regarding them. Though I think the latter has more potential. Plus you could also borrow elements from things like Bad Blood Predators, with no rules governing them at all... I mean take it to different places. Don't just do a half dozen "badasses" up against a Predator. We've gotten a lot of that. Take it somewhere.