She wasn't that bad in Deliver Us From Evil, but hopefully she doesn't get too much screen time. Her being cast as a scientist is pretty intriguing because maybe there is a part of the plot that revolves around people testing the Predator or it's DNA, which could be a new perspective.
As for the suburban part, I'm not too sure about it, but the fact that Shane Black has cited Close Encounters (similar setting) as a film that he will borrow elements from, I think he may have something very unique up his sleeve.