I'm sure Gearbox will be fine. Homeworld, the inevitable Borderlands 3, Brothers in Arms and that Borderlands collaboration project with Telltale will probably all bring them success because Pitchford knows what the fans want to hear. With that being said, they will get none of my money.
Whether Alien Isolation is successful or not, my dream game is a compilation of ports/HD remakes of previous Alien/Predator games. Aliens arcade, AVP Arcade, AVP and AVP 2 would definitely be in the compilation. I know Sega can make it happen.