You wouldn't even need to shoehorn any WY dudes into it at all - the game play should just maintain a tight focus on Newt and her survival. Amnesia - The Dark Descent did just fine with just 4 monster types.
You'd pick the game up right from the very point she sees her father with the facehugger on him. They get rescued, taken back to the colony and then her infected father is killed by the colony's first Alien.
It's not a Queen, so the alien starts to abduct people and transforms them into eggs in a secluded part of the colony, the eggs are discovered by some of the colonists - and some get facehugged, their unconscious bodies are recovered and taken back to the medlab. The parasites are removed but the victims don't survive. Easy continuity. It's really not a hard scenario to come up with that DOESN'T break canon or introduce desperately justified bull shit scenarios... a la Ripley's daughter.
As more colonists are abducted, there are less humans around to combat them. Sooner or later, a critical mass of aliens vs humans occurs and Newt finds herself alone, and constantly under threat of being captured and she fends against the invasion without confronting them - she can't do so directly, but she can run and hide. stealth her way around the colony during the day, hiding at night and cautiously seeking supplies during the day. They're always trying to catch her - but she outsmarts them every time, scavenging for food, setting alarms and possibly even crude traps to slow them down.
To me, that's a game that is highly deserving to be made. Maybe they will still embrace such a concept... we can only hope so, as all we really have at the moment is an announcement and rumor.