What I think is this Hammerpede will go from one person to another, infecting the crew with some virus that drives them crazy, possibly for some other purpose rather than just killing anyone. I'm also of the opinon it's these things the Jockey's unintentionally created that caused them to leave in the first place. Holloway I think will somehow come in direct contact with the black goo, either by accident during an expidition or possibly through David who it probably doesn't affect, but either way he won't be aware of it. This stuff seems like it could be full of tiny worms, I think will go on to transform Holloway into this human version of the Jockey we've seen so much of, but before it takes hold he has sex with Shaw causing her to become pregnant very quickly, the infection going into her baby not her which might be the key to a few things. The creature eventually removed from Shaw will become known as the Proto Face-hugger, which I think might actually change into something else by shedding it's skin, taking us into that last 8 minutes we've heard so much about. These things seem to be the most obvious I think, what happens after that is anyones guess....