Heavy attack twice then light attack once, or trophy kill them while they're stunned. If you know what you're doing predators go down easy.
The main thing to remember if you're attacking from the front is to block their focus lunge, as most pred players will usually pounce at you when they get within 30ft or so. Counter that attack, then hit them with the tail, then rip their face off. It's that simple.
Another good tactic is the pump fake. Start a heavy attack, then block straight afterward. This means the enemy will try to counter you with a light attack & immediately be met by another counter in return. It's an effective trick.