Now this quote does make sense if the following theory is correct,
Weyland is awoken later in the mission by David, after the original team find something he can find "usefull", probaly for his immortaility wish/peter pan complex.
So hes turning up properly mid 2nd act i assume,
He's then led out to get his "usefull" item which i assume will be a fully functioning SJ suit.
He then dons said suit, and it fuses with him creating the "big bald blue guy"tm then sets about trying to figure out how to fly the Derelict Ship, all the while having David along with him to help him work it out (scenes of blue guy and david in the orrery, Weyland heads off to earth and davids none too happy about it and leaves weyland to inform the rest of the crew just what the hell hes up to)
Now as soon as the fusion scene takes place (weyland into SJ suit) he becomes taller and "different" and then is played by one of those "body" actors, such as that 7" tall Ian Whyte guy,
Therefore Guy Pierce himself, is in the film for "only a minute" but his CHARACTER is in a lot of the film as Weyland played by different actors.
Please bear in mind this is all my theories, and could all be completely wrong!