I want to talk about World of Darkness
The The World of Darkness is a dark tabletop roleplaying game that encompasses Vampire: The Masquerade, Werewolf: The Apocalypse, Mages: The Ascension, Hunter: The Reckoning, Changelings: The Dreaming, Wraith: The Oblivion, Mummy: The Resurrection, Kuei-Jin: Kindred of the East, Demons: The Fallen, and Orpheus
The World of Darkness is one of my favorite settings, I'm not sure if we have a place for Non-ALIEN RPG Tabletop RPGs but I really want to discuss this setting.
For those who are unfamiliar with the World of Dark or Vampire: the Masquerade. There are thirteen distinct vampire Clans each with its own unique set of powers and curse. Now before I cover the clan weaknesses, I want to list general vampire weaknesses.
Sunlight
Fire
Requiring Blood for substance.
Weakness to True Faith
Frenzy is extremely dangerous for a Vampire since it can jeopardize their humanity and edge them closer to the Beast and once a vampire allows the beast to take completely over a vampire can become a Wight (Feral Vampire).
Okay let's start with Clan Brujah, their whole thing is being a rebel or at least this is how they are perceived by the other clans. Technically the Brujah are split between being rebellious thugs and passionate warrior-poets. Nonetheless their clan weakness is Violence. They can be trigger very easily and when they do it always in a frenzy.
Clan Gangrel are kind of like werewolf-wannabies vampires. They have control over animals and they can shapeshift into an animal or become werebeast-like. Their clan curse is after they frenzy a part of their animal aspect manifests on their bodies.
Clan Malkavian are the crazy vampires that can see the future! They all suffer from some kind of mental illness, most of them were mentally ill or autistic people in life but if a non-autistic person gets turned by one of these vampires, they'll gain a mental illness.
Clan Nosferatu, their curse is being hideously ugly but they are some of the chilliest vampires in the setting.
Clan Toreador, their curse is being obsessive with Art and pretty things. They have a reputation of being the hottest vampires in the setting but thats because they typically embrace Hot people, not that if you get turned you'll be hot.
Clan Tremere, they are blood mages, their clan weakness was originally being almost blood bonded with their sires but V5 changed this to having weak blood due to Tremere vampires were originally a cabal of mages that stole vampirism from a (near) extinct clan
Clan Ventrue, they are basically vampire politicians, their curse is having a refine taste in rare blood. They are also stoic, the refined taste in blood for an example: like needing to only drink from blonde people or smart people, and have served the vampire government, the Camarilla, as its leaders for centuries.
Clan Tzimisce, they are essentially a plastic surgeon's wet dream mixed with their worst nightmare. Their clan curse is that they need to be buried with their homeland's dirt. They can make monsters out of their ghouls and can shapeshift into down right monstruous forms.
Clan Giovanni (as of V5 they are now part of Clan Hecata), they are essentially Italian Mafia Vampires they only embrace people that want to join their family. Their clan curse is having painful bites.
Clan Ravnos, they are vampire thieves. Originally their clan curse was they had to have a compulsive crime, then it was changed to having a compulsion to they are just doom magnetics.
Clan Followers of Set (V5 now known as Ministry), they are religious vampires dedicate to the church of set. Their weakness was having double weakness to sunlight. Now its weak to any kind of light.
Clan Lasombra are ruthless aristocratic vampires, their clan curse is they have no reflection.
Clan Assamites (V5 now known as the Banu Haqim) are basically assassin Vampires. Their clan curse used to be that they grew darker with age before V5 replaced it to where they have to feed on someone who deserves punishment.