Indeed, in fact, it hinted that the Predators don't even seem to know about the Engineers.
One of the Predators discovers their existence by entering a cave of a primitive species made by the Engineers that he was hunting, he then sees the cave paintings of them pointing up at the stars and his obsession with them begins.
Then he encounters a statue of an Engineer when hunting a civilization of bug like aliens also created by the Engineers.
Then he eventually finds a hologram of an Engineer while hunting an advanced alien species.
These were all across the cosmos and when he finds the Engineer, there's no moment of intrigue or any non-hostile exchange of dialogue, just instant fighting as the Predator is too excited at having finally found his prey.