I listened to the entire podcast, it's mainly nitpicking (with all due respect). You just have to let go of Alien 1-3 and enjoy the prequels for what they are. A new story, new characters, etc. Otherwise we'd just get endless remakes of Alien and Aliens (I know some people say Covenant is a remake, but it had enough new material to be its own thing).
Each Alien film is like a reboot, anyway. It's what has kept the franchise alive. Otherwise it would be like Friday the 13th. So those wanting a direct sequel to Prometheus...... would not work IMO. Scott said what he wanted with Prometheus, and decided to start over and focus on the best thing to come out of Prometheus, David the android (I know some might disagree). I also prefer not everything explained, as it's science FICTION (another form of fantasy), in which you have to use your imagination to fill in the gaps. Main thing is whether you enjoyed the film or not.