I think I'd prefer the Wendigo/Sasquatch angle over a pair of Predators hunting the Comanche with basic weaponry, but as with anything, it would all depend on its execution.
In my head I could see the film work where the Sasquatch is dead within the first 20 minutes of the movie - a situation where the Comanche and the Sasquatch have been living in harmony for generations - not Harry and the Hendersons style mind you
- but a dangerous mutual respect like with the bear, not invading each other's territory, and both bringing a balance to the lands.
But one day, thanks to a Predator, some Comanche hunters stumble upon a fresh slaughtering of a Sasquatch spineless and beheaded, and all but one Comanche escape to tell the tale of that discovery.
A demon is among them! Then a hunting party for the demon must begin, to rid the lands of this unwanted evil.