The Predator franchise always had relatively self-contained stories. Yeah "Predator 2" and "Predators" refer back to the 1987 original, but they were largely independent stories in the Predator universe.
Could a sequel continuing Naru's story work? Possibly...although she has proven herself already to her tribe, so in a sense, her story arc is complete. The real question is what happens to that pistol, at least in the movie Predator universe (as opposed to the Predator comic universe, with that pirate story explaining Greyback getting that pistol).