This could be great or piss poor and I'm not sure which side of the fence I'm on ATM.
We all know it'll be Predator vs Wolverine or Punisher.
If they keep the franchises within their respective umbrellas EG - No Marvel crossovers and simply Alien or Pred or AVP content is generated then I think that's the "best" outcome. For me at least.
One thing I am interested in is does this mean Marvel/Disney have got one eye on more cinematic content? As I think Marvel budgets could really bring the franchises back to the fore. Well Pred seems to be better with shitty budgets like 1&2; but Alien with a massive budget to make Geiger-esque soundstages and sets could be incredible, IMO.
On te comics front, though - I think they'd do well with a rehash of the AvP Arcade Game and use San Drad as an Alt-World futuristic Californian Town (as The Predator introduced wormhole/dimension hopping tech, IIRC - as shit as that sounds). Maybe Yautja recon teams synthesised a training/battle android (salvaged from Weyland tech after a skirmish with a colonial ship?) based on Dutch after they watched Jungle Hunter's battle logs or something. And they use it to train hunters against to develop better but end up using it to fight Xenos.
That's just off the top of my head; but that sort of stuff would be more palatable than the "Hey bub" *snikt* nonsense I'm really hoping they don't churn out but likely will.