I'd only like it if it was some kind of dynamic AI that you could shut off away from you, like trap it in between IRIS vents like in Alien, but that it could work its way around to you in other ways. That way you'd need to manage resources that might not be weapons (welding torch, flares, hacking kit, ash style motion tracker).
Kind of like the very old Alien game I didn't play but read that you could use all members of the crew to kill the Alien a variety of ways.
If its just a bunch of scripted bullshit, I'm not for it either.
Maybe have the Alien draw you out by abducting crew members you could or could not go back for, have it start disabling the ship (I always found the lights being shut off in the first movie conspiracy like as well as the cat giving false readings) and you have to respond etc.
Maybe actually start out with the capacity to kill the Alien already, but if you shoot it actually eats through the hulls and shoots you into space.
I think it could be done, but it would have to be in a dynamic way where you one playthrough was the only enjoyment you got out of the game.
MP would be cool, have a ragtag crew of spacetruckers with limited gear confront the Alien.
It would be nice to have some capable NPCs you could send out to fix chores, that maybe you could monitor, only to have the Alien dynamically stalk them, and you have to try and keep them alive with your shitty ash style motion tracker.
There are ways to make it work I think, it would just evolve some intelligent AI.
Of course it should be able to kill corporate mercs as well.