An issue I stumbled across re-reading it recently, one part says Fire & Stone/Life & Death/& (by extension) Titan's Alien Trilogy happened mentioning the state of LV-223, the Onager, and the Aliens brought to the planet, saying the Alien is susceptible to the Pathogen but then in another part later on it says certain hives contain the Pathogen, created by the Aliens themselves, it's suitable the Alien is the only thing that's able to control it but it totally contradicts the aforementioned stories.
It already outed The Rage War by saying the Alien is unaffected by the vaccum, it's clear the contradictions only mount with time in regards to the aforementioned stories, just out them from canon and give my head peace.