I don't know why, but I get the impression 'Isolation 2' we'll be playing as Amanda on Renaissance station following the leads to her mother's whereabouts 😅
Everything Fede has talked about has 'happened' in some way or another - from the prequel comic book, to his crossover universes talk/stealth AvP (Badlands is looking like it might be the case). Given that, when asked about the shuttle, he made comments about the station being big and that Ripley may be doing her thing around that station at the same time as Rain and Co... but he didn't specify *which* Ripley... and given the inclusion of the save point phones around that station (presumably as Isolation Easter eggs) the station would lend itself to a game quite well...