It seems River of Pain seems to have got lost in all the other Alien Day and Alien: Covenant fun that was happening at the time. I recently relistened to it in preparation for getting a review written. In short, I really enjoyed it. However, if you disliked the book you'll probably still dislike the audio drama.
I really loved the cast. I loved having Salmon back. And Anna Friel was just amazing! I do think the cast was a little too big at times, though, and I lost track of the characters sometimes.
I loved they went and got the Hadley's Hope door sound effect. While I dig the Isolation sound effects, I would have preferred they went back and got the Aliens sounds for the creatures. Would have made it feel a little more at home.
Over all, I really enjoyed it. Wasn't without it's issues and I think I liked Out of the Shadows a little better over all but I still want to see more Alien adventures in this formats - adaptations of the Titan books or original.