Are they going to make the xenos more or less related to some man made oopsie, like them growing from the terraforming process gone wrong or some such? In a way, I think I would like to see very little other sentient creatures from outer space. This being human centric would be cool. The whole bugs = weapon thing had its success for years among certain fan circles, but if we can get something more ironic, creepy, human centric and perhaps even metaphysical, I think I'm for it.
That said, I hope it won't turn out into a thing where the ALIEN arc becomes a subplot like Pitch Black did in light of Chronicles (although I do enjoy the entire Riddick universe a lot). I'm quite well past beyond the point of spending huge amounts of time talking about ALIEN & co, but this movie may really bring this back to life.
One thing I think would be good is to show how the suits used in the first movie had some gadgets hidden underneath the filthy plates. Perhaps also something that explains why talking to Mother had to be done in a room with lots of LEDs and why a typing interface still seemed necessary, despite not requiring that much of textual input. Dallas was asking quite complex questions while typing a few words at best. Perhaps something like, you know... the room had a semi mind reading capacity? Something making exchanges with the ship's mind faster, but some manual confirmations still needed.