What has me the most worried is the lack of focus on the Aliens themselves and how you experience them in the game.
I can tell almost for certain that there's going to be tons of scripted crap, people getting pulled into vents where you can do nothing to save them because it's "scary," and Aliens coming from the same predictable locations until the 'last stand' areas, in which they'll spawn en masse and charge down one of many corridors.
I hope I'm wrong, because that's my biggest deal-breaker for the game. I can tolerate anything if the actual me ->shooting -> the alien is like the movie and immersive.
From everything they've said, it's like they care more about the lighting and their neat story and the fan service than they do about the actual aliens themselves. Those priorities are worrisome. They should be bending over backwards to make the gameplay as unique, realistic, and intense as possible, so that each Alien truly feels like an individual threat.
Those are the kinds of things I wish we'd been hearing from Pitchman the whole time, things about the Aliens themselves and how the combat is going to be dynamic and intelligent. Hell, the Aliens in AvP 2010 were good enough to make Survivor mode enjoyable even though the levels were closed-in and terribly small.