Present day, ultra gritty/realistic, war torn Middle East setting.
I'd love for it to go to unexpected places that we haven't seen in the films. I don't want it to be a glossy update of the ol' group of bad ass soldiers getting widdled down to just one. I think I'd rather see a war with these things at this point. Tactical urban warfare with a Predators.
I've day dreamed the "Predator Home World" plot a million times over and have mused about them for years on these boards. Space Arena battles, Predator culture, women/children, other species of aliens and their roles. I don't think we'll be seeing any of that.
I think if they manage to class it up a bit and make it really scary and intriguing again I'd be happy.