I don't want any more Predator movies in space,. Although I do wish we got to see Royce and Isabelle make it home somehow, it would seem almost erratic to go back and resume the story of Predators after The Predator.
I want more earth-based films. A film inspired by Cold War the same way P2 was inspired by Concrete Jungle could be good.
Or even better, as I saw somebody say the other day, a film set during the Mayan civilisation (sort of like Apocalypto featuring a Predator) could be cool. You could have a Pred who doesn't use plasmacasters, in order to even the playing field, and you could have tribal warriors teaming up to take it down. Another take on the "rite of passage" theme from AVP, but inverted so that it is the humans uniting to hunt the hunter.