Whether or not they choose to ignore 3 and AR (and I think in an age where both DC Comics and Sony are rapidly rebooting their superhero properties and Fox is struggling to retcon their way out of their early, messy X-Men films, that's very possible), there is beyond zero chance that they will ever acknowledge the ACM video game as canon. That's the kind of fannish thinking that polluted the Star Wars fandom, thinking all those f**king awful books would be acknowledged for Episode VII. It will never happen. All that crap means nothing.
I think it would be a mistake to go on from Aliens and ignore the other sequels, because unfortunately what's done is done. But I think it stands a good chance of happening with this film. Nostalgia is king these days, 'remixing' and 'rebooting' unpopular history is in. The new Terminator film, which looks hilariously awful, is making a bold attempt to undo their last two terrible sequels by adding even more crazy shit on top of the existing mess. And I frankly don't find Neill Blomkamp to be very deep. He made a wonderful allegorical shoot-'em-up about refugees vs. Evil Corporations, and then he made another one with stars which was absolutely terrible and almost ankle-deep. Chappie looks like something very similar. And his designs look like the same thing: Ripley and Hicks play chaos agents in the beautiful secluded corporate palace of Weyland-Yutani! Pew pew! Time to get into my Engineer exosuit and wreck shop!
I mean, it might be a fun ride but a brlliant movie which deeply explores the interconnections of alien life and the darkness of the unknown... I am not seeing that here thus far.