I've now got mine, and have had a solo play-through. First up, I'm missing two cards: one Grunt, and one of the Hive cards from ALIEN's Objective #2 (I don't know which one, naturally). Inexcusable.
BUT, the game is fun. I really like how the excitement ramps up as you complete Objectives. I played the ALIEN scenario, and actually had a fairly easy time of it until Objective #3, when the self-destruct was set and the Perfect Organism was in my face; I'd have Parker use the shock tube to zap him back down the complex, but those Event cards would bring him right back into my face again. I didn't get the chance to be blown up in the explosion, but at least I know I took that sucker down with me.
A note about solo play: I see that if you encounter Ash, you can't kill him unless another player Coordinates with you. So unless I'm missing something, if you draw him in a solo game, you're doomed.
Some of the art is pretty embarrassing, but you get over that pretty quickly. I think my favourite art is MU-TH-UR's Advice (I might have that name wrong).
I'm annoyed that the Jones card is called 'Jonesy'. THE. CAT'S. NAME. IS. JONES. That's a pet-peeve of mine. I'd start a thread about it here somewhere, but I'd probably be attacked.
All in all a very fun game, and I look forward to playing it with others.