Writer Damon Lindelof has done a lengthy video interview for The Kevin Pollak Chat Show. He starts talking about Prometheus on 2:18:00. There’s no major spoilers. He recalls how got to work on the Prequel. Let’s not forget, John Spaihts originally wrote the film as an Alien Prequel, and then Lindelof came on board to re-write his script. His script still has elements from Spaihts’ script and it took him two weeks to write his first draft.
How much Prometheus is related to Alien is still up in the air. He says the movie takes place in the same world as Alien but doesn’t mention story specifics. Thanks to Darkoo for the news.