In an interview with Eurogamer, SEGA West CEO Mike Hayes said that they are not currently considering a sequel to Aliens vs. Predator.
“[AVP] was so successful that naturally you would think you want to do a sequel,” Hayes reasoned. “But we already had Aliens: Colonial Marines in the pipeline at Gearbox.” “The Aliens universe is so interesting that there are different things that we can do before we go back to an idea of sequelisation,” Hayes added. “There’s a lot more we can do first before we would consider doing a sequel on AVP.”
Rebellion expressed interest in doing a sequel after the game had been released but of course, Sega then dropped support for the game only a few months after its release.