According to Vulture, actress Charlize Theron is being sought by Fox for a role in the Prequel:
“Regardless, we’re told that Fox is having the role rewritten so that it’s larger and befitting, if not of Theron, then at least of someone of Theron’s stature. We’re also told that the South African beauty should get the new version of the Alien script sometime this week and make her decision soon.”
This should be taken with a grain of salt, however, as Vulture’s last Alien Prequel news was debunked as incorrect. Thanks to Shasvre for the news.