My sum-up after the Spider-man news:
I think Fox is going to greenlight a Fantastic Four/X-Men movie as soon as possible, rather than letting the characters die and go to Marvel's hands. I think they will try to strengthen their licenses, they have to do something to compete with the Marvel+Sony alliance.
For the trailer it looks like they have a diamond in rough with Fantastic Four. Even if the first movie doesn't do too well, I think the Fantastic Four characters could appear as support characters in new X-Men movies. I'm convinced F4 can be the great connective tissue in making a transition to more sci-fi oriented stories, there are things they can do no mutant is able to. That would be the way to start introducing spaceships and such and finally do a decent X-Men: Phoenix movie.
I would picture Fantastic Four 2 being a fight against Galactus, they're able to dispell him with a device but then they realize they simply transported him into an alternate universe. The F4 go themselves into that universe via a spaceship, and guess what? It's the X-Men universe in the early 90s, they're effectively moving! That way they could interact with the X-Men: Apocalypse cast and begin a proper Shi'ar/Phoenix saga.
Kinberg has said he thinks he's able to pull off the crossover, I'm pretty sure Fox will greenlight this soon.
While mutants are a huge universe indeed, Fox needs a little more diversity to be able to set up bigger stories and a much richer universe like what Marvel does (just see, Apocalypse will not even be related to aliens in X-Men: Apocalypse, and there's a big space opera universe out there to explore -- now with Star Trek, Star Wars and GotG, space is hot again).
And Fantastic Four are the only other property they have left. F4 movie does look good and interesting, and more important than that, revelant (that "high science" speech from the beginning is just wow for a sci-fi/superhero cinematic universe franchise) and different to the X-Men. I think that can be a great aid to strenghten Fox in competition with Marvel+Sony and WB.
Seeing how Marvel+Sony is coming together, and the huge offer WB+DC has, I think it'd be urgent for them to connect their properties in order to create something stronger and take advantage of the little that is left out of Marvel Studios's control...