I am going to hypothesize from the other side of things.
1st - I remember seeing decades ago, a tid bit about combining the series - in a predator movie... I believe it was 2 - there is a queen alien's head in the ship - someone will have to check, but it may have been made up in my head since it was a long time ago (but I'm young so that looks good lololol) 2nd, they had issues picking the storyline for avp was tricky for the directors to pick. Everyone whom can, confirm this for me - now is where I point out some features from the alien species... so try to follow me, as all of these movies from this series seem to all be genetic in nature from the beginning of the series to the end... here it goes.
1) First I have to explain some genetics to make WHAT happened in Prometheus correct - which then can also explain the predators and everything else in the AVP/P series' as a while.
Take a horse... if it mates with a horse it makes a horse
If a horse mates with a donkey it makes a mule
A mule is infertile - it can't make more...
Horse = 1 species
Donkey = 1 species
Mules = 1 infertile species
Of these creatures - mules (male) cannot produce viable offspring aka sperm (think of them like an infection... sorry men - i feel you) and think of the female mules as the queen in Resurrection - forgive me ladies. - NOW it is safe to say that if we consider that bit of biology to be factual - and it is - then let us consider the following from the movie
The beings from this movie ARE NOT THE CREATORS - they brought the FIRE to HUMANITY... aka they stole it from the gods... and I ALSO BELIEVE there is a CLUE in the AVP dialog... as the "GODS/GUARDS Need their WEAPONS" - You can say there is no relation but if the word GOD was not so universal, and uniformal instead, then indeed we are referring to Predators as we call them every time we say the word 'god'... back to the beings that STOLE the fire, Let me address the name of the ship and the connection to the beings.
I am going to then state that the name of the ship, under the lore of the knowledge above - was named for its purpose... which of course was to steal the 'fire.' Under our culture, Prometheus is the titan that stole the fire from the gods, so in essence - the science that lead to our prehistoric sense of religious deities then adequately described what the Engineers as you call them, did to the predators, and thus we later did to the engineers (and named our ship to do) in the process under culturally inspired names for our ships that thus depicted indirectly events that were recorded in the lore and lay of our own land!!! damn that's deeeeeeeeeeep.
So then what was the fire??? Well is that not obvious. The predator's used this bio-weapon to reign supreme within the universe - it was changed and managed by their tech. experts. But it was stolen by the engineers and although predators may have enjoyed 'finding' us and 'using us' they then learned in their discovery of how we came to existence and perfected this bio-weapon and the xeno's, and we were put on the list of 'things to destroy'.
HOLD IT... this sounds like the same take, so how does it connect differently?
-You remember the DNA and biology bit I said about the aliens above? - The engineer was the horse, she was the Donkey and the alien is the mule... and if you think of the aliens as bacteria or viral, the aliens dont need to mate with a race - because the male is infertile but the queen lays eggs, and if it meets with a host it can create more - and as we know, ripley mated with a female- and it worked - think of the goo, as the step before the horse - and that means...
ALLLLLLLLL of this said... what was that thing at the end of the movie then? - It means that she gave birth to a 'mule' alien/metheous baby. And this was bacterial in nature, and when mixed with the Engineer created a similar race of beings to the Alien race.
If the genetics of this had to be explained, which by her labor causes the indirect explanation of it even though you'd need to know genetics to know it - then that goo was the weapon used to kill them, not us - in fact, that goo may have had effects on us - but realistically what that did to the dna of a worm could only pale in comparison to what it would do to an Engineer... and wow, it didn't kill us, remember... although it had effects... zombie like effects (which is kind of dumb imo)